Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction (Adv. Sci. 48/2026)
Year: 2026
Type: article
Abstract: Kaempferol Attenuates Spaceflight-Associated Knee Cartilage Degradation Spaceflight and microgravity can degrade knee cartilage through NOX4-mediated inflammation, senescence, and mitochondrial dysfunction. Kaempferol, a natural flavonoid that binds to NOX4, serves as an effective countermeasure to reverse this cartilage loss. More details can be found in the Research Article by Afshin Beheshti, Hang Lin, and co-workers (DOI: 10.1002/advs.76477).
Source: Advanced Science
DOI: 10.1002/advs.77032
Authors: Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,730
OpenAlex ID: W7204588456
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