Work

From serendipitous reaction discovery to antimycobacterial opportunities: general access to scarcely reported 2-((pyrrolin-5-yl)amino)phenols

Year: 2026

Type: article

Abstract: A crystallographic fragment screening unveiled a previously undetected isomerisation that opened access to a scarcely explored ligand chemotype.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d6ob01100d

Authors: Dylan El Faudel, Gabriel Publicola, Chantal Carayon, Frédéric Robert, Caroline Toppan, Judith Alric, Coralie Carivenc, Lionel Mourey, Virginie Nahoum, Stéphanie Ballereau, Laurent Maveyraud, Yves Génisson

Institutions: Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, Synthèse et Physicochimie de Molécules d'Intérêt Biologique, Université de Bordeaux, Institut des Sciences Moléculaires

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: hybrid

Funders: Infrastructures en Biologie Santé et Agronomie, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse, Centre National de la Recherche Scientifique, Université de Bordeaux, Université de Montpellier

Awards: Phosphopantetheinyl transferases as drug targets for the treatment of infectious diseases and colonization of the gut by multidrug-resistant bacteria, G4765036411, G5420063140, G7080048889, Designing Inhibitors of Phosphopantetheinyl Transferases Of Pathogenic bacteria

OpenAlex ID: W7204597886

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