Development and Validation of a Stability-indicating Uplc Method for the Simultaneous Estimation of Ombitasvir, Paritaprevir and Ritonavir in Bulk and Pharmaceutical Dosage Forms
Year: 2026
Type: article
Abstract: A rapid, accurate, precise and stability-indicating UPLC method was developed and validated for the simultaneous estimation of Ombitasvir, Paritaprevir and Ritonavir in bulk drugs and pharmaceutical dosage forms. Chromatographic separation was achieved using a BEH C18 column with 0.01 N potassium dihydrogen phosphate buffer and acetonitrile (60:40, v/v). The method was validated according to ICH Q2(R2) guidelines and demonstrated excellent specificity, linearity, accuracy, precision, robustness and sensitivity. Forced degradation studies confirmed its stability-indicating capability. The developed method is suitable for routine quality control and stability testing of the combined pharmaceutical formulation.
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7204620521
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