Work

A lysis-derived PMSF and orthovanadate oxidant defines a distinct cysteine-engagement profile

Year: 2026

Type: article

Source: Cell chemical biology

DOI: 10.1016/j.chembiol.2026.08.005

Authors: Bethany E. Schaffer, Jung Seung Nam, Ceci A. Cohen, Clementina Mesaros, Robert W. Myers, Leigh Baxt, Kathryn E. Wellen, Lewis C. Cantley, Noah Dephoure, Nathaniel W. Snyder, Iok In Christine Chio, John Blenis

Institutions: Weill Cornell Medicine, Columbia University Irving Medical Center, Herbert Irving Comprehensive Cancer Center, University of Pennsylvania, Tri-Institutional Therapeutics Discovery Institute, Abramson Cancer Center, Harvard University, Dana-Farber Cancer Institute, Cornell University, Temple University

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, Weill Cornell Medical College, University of California, San Francisco, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Exploring the regulation and function of gap junction-mediated signaling in glioblastoma multiforme, The role of NAGK cysteine deprotonation in nutrient stress and cancer progression, Cancer Pharmacology, Hypoxic incubator for physiological cell culture research, G8760597890, Mitogenic and Oncogenic Regulation of ERK/RSK Signaling, Buffett Cancer Center Support Grant, Characterizing the role of MSRA in pancreatic tumorigenesis, ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling, Cancer Center Support Grant

OpenAlex ID: W7204751698

FWCI:

Cites: 88

Cited by:

Related to: 10