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Counterion modulation of aza-BODIPY aggregation behaviour for boosted sonodynamic therapy

Year: 2026
Type: article
Abstract: -paired aza-BODIPY dye (BT-Cl) formed nanoparticles with the smallest hydrodynamic diameter and yielded the highest levels of reactive oxygen species (ROS). BT-Cl NPs also displayed potent sonodynamic cytotoxicity toward both 4T1 and U87-MG cells. Consequently, BT-Cl exhibited excellent tumor growth inhibition with minimal side effects. Overall, this work underscored the critical role of noncovalent ion-pairing interactions in governing small-molecule sonosensitizer aggregation and provided a facile approach for the rational design of high-efficiency sonosensitizers.
DOI: 10.1039/d6sc05519b
Authors: You Dou, Guoyan Fang, Junhua Zhang, Yuting Wang, Yuntao Li, Sheng Qiu, Jun Li, Yao Sun, Junrong Li
Institutions: Zhejiang Chinese Medical University, Central China Normal University, Huzhou Central Hospital, Jinyintan Hospital, Huazhong Agricultural University, Jinfeng Laboratory
Language: English
Open Access status: diamond
OpenAlex ID: W7204771215
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