Year: 2026
Type: review
Abstract: Proximity is a fundamental prerequisite for a diverse range of biological processes. Chemically induced proximity strategies exploit this principle to achieve the controllable modulation of targets of interest through programmable biomolecular interactions. By rewiring biological interactions, induced-proximity technologies can regulate protein stability, activity, localization, transcription, and signaling. Recent advances have greatly expanded the repertoire of recruitable effector proteins, enabling the manipulation of challenging targets previously considered intractable. In this review, we summarize the conceptual evolution and mechanistic diversity of induced-proximity technologies, highlighting platforms for targeted protein degradation, stabilization, post-translational modification editing, protein relocalization, and transcriptional control.
Source: ACS Bio & Med Chem Au
Authors: Xiaokang Jin, Chen Zhou, Xiaoyu Zhang
Institution: Northwestern University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,500
OpenAlex ID: W7204792701