Work

Bioorthogonal dual-channel imaging of NO and H 2 S reveals redox imbalance in atherosclerotic plaques

Year: 2026

Type: article

Abstract: DBCO-BOD-NH is a dual-channel probe that harnesses bioorthogonal chemistry for in situ NO/H 2 S imaging in atherosclerotic plaques. It reveals that plaque progression elevates NO while depleting H 2 S, and diabetes worsens this redox imbalance.

Source: Chemical Science

DOI: 10.1039/d6sc06239c

Authors: Jiheng Xu, Xin Xia, Ping Li, Yue Tang, Wen Zhang, Hui Wang, Wei Zhang, Bo Tang

Institutions: Shandong University, Shandong Normal University, Qilu Hospital of Shandong University, Laoshan Laboratory

Language: English

Topic: Sulfur Compounds in Biology

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Natural Science Foundation of Shandong Province

Awards: G2457401610, G4379831452, G7068454824, G8425225936

OpenAlex ID: W7204819746

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