Work

Organocatalytic asymmetric electrochemical synthesis of epibromohydrins from allylic alcohols

Year: 2026

Type: article

Abstract: O biphasic system, a range of allylic tertiary alcohols were smoothly converted into the corresponding bromoepoxides in high yields and with high enantioselectivities. Control experiments and cyclic voltammetry studies suggested that stereocontrol is sensitive to the balance between anodic bromide generation and phase-transfer-mediated trapping. This strategy is complementary to the conventional synthesis of epibromohydrins by chemical oxidation.

Source: Chemical Science

DOI: 10.1039/d6sc05589c

Authors: Zhengyu Han, Ming Fang, Peinan Shang, Shuxuan Liu, Hai Huang, Jianwei Sun

Institutions: Changzhou University, Hong Kong University of Science and Technology

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Research Grants Council, University Grants Committee, Innovation and Technology Commission