Work

Adipocyte β3-adrenergic receptor signaling attenuates leptin production but is dispensable for fasting induced leptin suppression

Year: 2026

Type: article

Abstract: This study introduces a novel Adrb3 transcriptional block mouse model that enables global inactivation or adipocyte-specific reexpression of β3-adrenergic receptor signaling. Using this approach, we demonstrate that adipocyte β3-adrenergic signaling directly restrains leptin production under basal and stimulated conditions but is dispensable for fasting-induced leptin suppression. These findings refine the role of sympathetic signaling in adipose tissue and clarify mechanisms governing leptin regulation.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00083.2026