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A pilot study investigating the effect of serum 25-hydroxyvitamin D on device-estimated sleep metrics in young black women: a single-arm open-label clinical trial

Year: 2026

Type: article

Abstract: Study Objectives: Vitamin D deficiency has been linked to poor sleep health outcomes in the general population. Black women (BLW) experience a higher prevalence of vitamin D deficiency and short and disturbed sleep compared with other races. Therefore, this study tested cross-sectional associations between serum 25-hydroxyvitamin D concentration ([25(OH)D]) and sleep health estimates in young adult BLW, followed by an 8-week vitamin D supplementation intervention. Materials and Methods: Forty-three 18-30-year-old BLW underwent blood sampling for serum [25(OH)D]. Sleep metrics were derived from 14-days of wrist accelerometry. Thereafter, participants with [25(OH)D] <30 ng/ml (N = 16) completed an 8-week vitamin D3 supplementation intervention (5000 IU/day) and repeated blood sampling and sleep monitoring. Results: > .21). Conclusions: [25(OH)D] was cross-sectionally associated with sleep efficiency and SOSD, however, intervention results from this pilot study do not demonstrate a beneficial effect of vitamin D on several device-estimated sleep metrics in young BLW. Clinical Trial Registration: Effects of Vitamin D on Cardiovascular Health in Black Women, https://clinicaltrials.gov/study/NCT05656742?locStr=Delaware&country=United%20States&state=Delaware&cond=Vitamin%20D%20Deficiency&term=blood%20pressure&intr=Vitamin%20D&rank=1 Registered on ClinicalTrials.gov ID NCT05656742.

Source: SLEEP Advances

DOI: 10.1093/sleepadvances/zpag096