IMGT-NC Engineered Variants of INN Therapeutic IG or Antibodies and Related IgSF Proteins (TR, FPIA and CPCA): Bridging Sequences, Structures and Functions for AI
Year: 2026
Type: article
Abstract: IMGT®, the international information system® (IMGT), was created in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS) in Montpellier, France, to deal with and to manage the huge diversity of immunoglobulins (IG) or antibodies and T-cell receptors (TR), which are the antigen receptors (AR) of the adaptive immune response (AIR) of jawed vertebrates. The founding of IMGT® marked the advent of immunoinformatics, a new science which emerged at the interface between immunogenetics and bioinformatics. The biocuration of the IMGT data (IG and TR sequences, genes and structures) and the implementation of the IMGT system (7 databases, 17 tools, 25,000 Web resources pages) are based on the IMGT Scientific chart rules (keywords, labels, nomenclature, numbering…) generated from the IMGT-ONTOLOGY axioms and concepts. The IMGT nomenclature (IMGT-NC) and the IMGT unique numbering, the two pillars of immunoinformatics, have been used to define 335 engineered variants for effector properties and formats of therapeutic antibodies (including 12 chimerisotypes) and TR, fusion proteins for immune applications (FPIA) and composite proteins for clinical applications (CPCA). IMGT-NC engineered variant names from the World Health Organization (WHO) International Nonproprietary Name (INN) programme descriptions contribute to the common language for immunoinformatics and artificial intelligence (AI).
Source: Biomolecules
DOI: 10.3390/biom16091264
Author: Marie-Paule Lefranc
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,258
OpenAlex ID: W7204894526