Work

Durynes G-I, antiproliferative polyacetylenes from Cribrochalina vasculum and their chlorinated decomposition products

Year: 2026

Type: article

Abstract: values in low micromolar ranges. Analogues with the addition of chlorine to the central olefin showed reduced cytotoxic activity, while the chlorination of the olefin of the alkenyl carbinol group was shown to diminish the activity of the scaffold.

Source: RSC Advances

DOI: 10.1039/d6ra05103k

Authors: Lucero Martinez-Fructuoso, Susan Ensel, Rhone K. Akee, Brian D. Peyser, John R. Britt, Jason R. Evans, Barry R. O'Keefe, Tanja Grkovic

Institutions: National Cancer Institute, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States), Hood College, Center for Cancer Research

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute

Awards: G1234541941, G3503792436, G386607036, G4585269469, G4689185066, G6252953675

OpenAlex ID: W7204902001

FWCI:

Cites: 25

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