Facilitation of Ion Transport Across a Bilayer Lipid Membrane Induced by the Inhalation Anesthetic Sevoflurane
Year: 2026
Type: article
Abstract: Sevoflurane significantly enhanced ion permeability across a bilayer lipid membrane (BLM). It is a typical inhalational anesthetic with a dielectric constant (8.1) higher than that inside the BLM (≈2.0). An increase (1.04 times) in the inner dielectric constant of the BLM is proposed to result from the accumulation of sevoflurane within the membrane. This increase is responsible for the facilitation of ion transport by enhancing the distribution coefficient of the electrolyte ions (17.6 times).
Source: Electroanalysis
DOI: 10.1002/elan.70218
Authors: Hirotaka Matsumoto, Keisei Sowa, Yuki Kitazumi, Osamu Shirai
Institution: Kyoto University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7204906443