Work

Recent Applications of Propylene Carbonate as a Solvent in Sustainable Organic Synthesis

Year: 2026

Type: article

Abstract: Solvents are essential components for organic synthesis and are widely used across various industries. However, conventional solvents are frequently toxic volatile organic compounds (VOCs) that contribute significantly to waste generation and environmental pollution. This has driven the need to develop sustainable alternatives that maintain efficacy without the associated hazardous properties. Propylene carbonate (PC) has emerged as a promising green alternative for sustainable organic synthesis. As a polar aprotic solvent with similar physicochemical properties to acetonitrile and acetone, PC has been shown to afford high yields and selectivities comparable to those of traditional solvents in a wide range of synthetic transformations. It possesses favourable characteristics, such as low toxicity, high dielectric constant and solvation capacity, biodegradability and low vapour pressure. High thermal stability provides significant capacity for reusability across multiple reaction cycles with minimal loss of efficiency, a crucial feature for reaction scale-up. Moreover, PC can be readily prepared from propylene oxide and carbon dioxide, an abundant waste greenhouse gas, in a 100% atom-economical process. With an increasing number of reports on the topic, this paper presents an updated review of both the preparation and applications of PC, addressing methodological advances and new transformations.

Source: ChemSusChem

DOI: 10.1002/cssc.71001

Authors: Laura G. Aguilar‐Sanchez, Christopher R. Jones

Institution: Queen Mary University of London

Language: English

Topic: Chemistry and Chemical Engineering

Subfield: Environmental Chemistry

Field: Environmental Science

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Estimated APC paid: $4,550