Work

Multivalent peptides for blood–brain barrier translocation, cell penetration and microRNA-21 inhibition in glioblastoma

Year: 2026

Type: article

Abstract: BBB model and enabled the functional silencing of miR-21-5p in GBM cells. Together, these findings pave the way for peptide conjugates as novel therapeutics for silencing miRNA expression in brain cancer.

Source: RSC Chemical Biology

DOI: 10.1039/d6cb00229c

Authors: Talhat Chaudhry, Marco Cavaco, Vera Neves, Miguel A. R. B. Castanho, Lauren Tonge, Francesca Giuntini, Adam Schofield, Christopher R. Coxon, Kehinde Ross

Institutions: Liverpool John Moores University, University of Lisbon, Gulbenkian Institute for Molecular Medicine, University of Edinburgh

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962

Funders: European Commission, Liverpool John Moores University, HORIZON EUROPE Framework Programme, Engineering and Physical Sciences Research Council, Fundação para a Ciência e a Tecnologia

Awards: G330676721, iMM-CARE: BOOSTING CLINICAL RESEARCH FOR THE BENEFIT OF SOCIETY, Instituto Gulbenkian de Medicina Molecular, G517441825, Instituto de Medicina Molecular João Lobo Antunes, G6997658380

OpenAlex ID: W7204917213

FWCI:

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