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Investigation of Choroid Plexus Alteration and Its Associations With White Matter Hyperintensities in Myotonic Dystrophy

Year: 2026

Type: article

Abstract: CSF-mediated inflammatory activity has been shown to be related to choroid plexus (ChP) alterations, whose relevance as a biomarker for neuroinflammatory activity is of crucial importance for several diseases. Because missplicing of the ChP and CSF homeostasis alterations have recently been suggested to be a driver of pathogenesis in myotonic dystrophy type 1 (DM1), this cross-sectional study aimed to examine ChP volumes and their relationship to white matter hyperintensities by the use of MRI to elucidate ChP as a potential biomarker in DM.

Source: Neurology Open Access

DOI: 10.1212/wn9.0000000000000167

Authors: Britta Krieger, Christiane Schneider-Gold, Erhan Genç, Onur Güntürkün, Barbara Bellenberg, Carsten Lukas

Institutions: St. Josef-Hospital, Ruhr University Bochum, Leibniz Research Centre for Working Environment and Human Factors

Language: English

Topic: Genetic Neurodegenerative Diseases

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7204925118

FWCI:

Cites: 46

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