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Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis (Adv. Mater. 49/2026)

Year: 2026

Type: article

Abstract: Cognitive Impairment Inspired by the Chinese myth of Nezha, the Janus “magic pill” shows an asymmetric structure: the Au domain with RVG peptide targets neurons, while the mSiO2 domain with TPP ligands homes to mitochondria, encapsulating vitamin B2. A mitochondrial boat floats on a neuronal surface, where ROS are scavenged as the pill approaches, symbolizing precision delivery and hierarchical targeting. More details can be found in the Research Article by Kai-Run Zhang, Xiaomin Li, Jun Gao, Yue-Hua Liu, and co-workers (DOI: 10.1002/adma.73920).

Source: Advanced Materials

DOI: 10.1002/adma.74796

Authors: Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu

Institutions: Fudan University, Shanghai Stomatological Hospital, Shanghai Jiao Tong University, Shanghai Ninth People's Hospital, Nanjing Medical University, First Affiliated Hospital of Anhui Medical University, Anhui Medical University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7204928911

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