Year: 2026
Type: article
Abstract: Aggression in mental disorders (AMD) poses a challenge for everyday clinical practice and has far-reaching societal implications. The biological foundations of the different manifestations, developmental trajectories, and transdiagnostic and disorder-specific deficits remain largely unknown. One reason for the apparent lack of understanding of the complex mechanisms underlying AMD is the heterogeneity of both aggression and mental disorders themselves. This, in turn, hinders progress in developing effective prevention and intervention strategies. Therefore, a collaborative approach between clinical and experimental neuroscientists is required to address this issue comprehensively and in a multimodal manner. The proposed initiative aims to advance knowledge on the biological bases of AMD and its developmental course. The Transregional Collaborative Research Center 379 (TRR) will follow the Research Domain Criteria (RDoC) framework, investigating multiple aspects that characterize aggression: genetic and molecular mechanisms as well as hormonal, neural, and associated behavioral systems. Thus, the TRR aims to identify biosignatures of AMD based on multidimensional pathways that underlie the different manifestations of aggression to enable the development of tailor-made biosignature-specific prevention and intervention.
Source: Der Nervenarzt
Authors: Ute Habel, Sabine Herpertz, Andreas Reif, Ute Habel, Sabine Herpertz, Andreas Reif, Lisa Wagels, Vanessa Reindl, Kerstin Konrad, Nathalie Holz, Tobias Banaschewski, Christine Freitag, Christine Ecker, Andreas Chiocchetti, Gabi Ende, Klaus Mathiak, Christian Paret, Michael Plichta, Heike Tost, Carmen Weidler, Natalia Chechko, Katja Bertsch, Christian Schmahl, Thomas Frodl, Aet O’Leary, David Slattery, Marc Spehr, Wolfgang Kelsch, Wolfgang Weber-Fahr, Jana Zweerings, Michael Hanke, Christoph Korn, Corinne Neukel, Wolfgang Retz, Oliver Tüscher, Andreas Meyer-Lindenberg
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $3,390
Funder: RWTH Aachen University
OpenAlex ID: W7204946522