Work

Plant Sterols and Metabolic Health: Current Evidence on Insulin Resistance and Type 2 Diabetes Mellitus

Year: 2026

Type: article

Abstract: Plant sterols are naturally occurring bioactive compounds widely recognized for their cholesterol-lowering effects. This narrative review critically evaluates current evidence regarding the role of phytosterols in insulin resistance, glucose metabolism, and type 2 diabetes mellitus (T2DM). Literature was collected from PubMed, Scopus, and Google Scholar for studies Published between 2000 and 2024 using pre-defined keywords related to phytosterols, insulin resistance, and T2DM. Evidence from in-vitro and animal studies suggests that phytosterols may influence AMPK, PI3/Akt, and GLUT4 signaling pathways and may improve metabolic homeostasis. However, evidence from human clinical trials remains limited and in-consistent. Current findings strongly support the lipid-lowering benefits of phytosterols, where as their role in glycemic control requires further validation through well-designed clinical studies.

Source: Hacettepe University Journal of the Faculty of Pharmacy

DOI: 10.52794/hujpharm.1697229

Authors: Partha Deb Roy, Vadivelan Ramachandran, Tharani M, Kalirajan Rajagopal, Venkatesh Gunasekaran, Ruchı Tıwarı

Institutions: JSS Academy of Higher Education and Research, JSS College of Pharmacy, PSG College of Pharmacy

Language: English

Topic: Natural Antidiabetic Agents Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: JSS College of Pharmacy, Department of Science and Technology, Ministry of Science and Technology, India