Supplementary Figure 3 from Archetype Analysis of Lung Adenocarcinoma Premalignancy Links Heterogeneity in Premalignant Lesions to Diverging Features of Invasive Disease
Year: 2026
Type: supplementary-materials
Abstract: GSEA of Hallmark gene sets among genes associated with distance from archetype Bar plot stratified by archetype and categorized by pathway type to show significant positive associations (FDR<0.05) of mSigDB “Hallmark” gene sets with distance from archetypes using Gene Set Enrichment Analysis. Using limma with a model that included distance from the archetype, study, and RNA quality (Methods) as fixed effects and patient as a random effect, genes were ranked by t-statistic for their association with distance from each archetype. Bars are colored based on value of normalized enrichment score for each gene set, and only sets with a positive normalized enrichment score and FDR<0.05 are shown.
Authors: Kelley E. Anderson, Linh M. Tran, Kostyantyn Krysan, Yohana Kefella, Lingge Yu, Gregory A. Fishbein, Erika F. Rodriguez, Maryam Shabihkhani, Daniel P. Stefanko, Emily Green, Gang Liu, Hanqiao Liu, Sherry Zhang, Erin Kane, Mitra Mehrad, Avrum E. Spira, Steven M. Dubinett, Eric J. Burks, Sarah A. Mazzilli, Marc E. Lenburg, Jennifer E. Beane
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7204995715
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