Supplementary Figure 1 from Archetype Analysis of Lung Adenocarcinoma Premalignancy Links Heterogeneity in Premalignant Lesions to Diverging Features of Invasive Disease
Year: 2026
Type: supplementary-materials
Abstract: PML-derived module co-expression (A) Density plot of correlation of each gene’s expression values to module GSVA score stratified by genes within the module and genes outside the module for all PML data (left) and PML data from each cohort (B-D) Boxplots of GSVA scores computed for each PML-derived module across (B) GSE102511 samples (n = 47 samples) stratified by module and colored by histology. Asterisk (*) indicates histology is significantly different from AAH samples (linear mixed effects model with histology as fixed effect and patient as random effect, p < 0.05) (C) GSE193725 samples (n = 51 samples) stratified by module and colored by histology. Asterisk indicates histology is significantly different from AIS/MIA samples (linear mixed effects model with histology as fixed effect and patient as random effect, p < 0.05) (D) GSE166720 samples (n = 50 samples) stratified by module and colored by histology. Asterisk indicates histology is significantly different from AIS/MIA samples (linear model, p < 0.05).
Authors: Kelley E. Anderson, Linh M. Tran, Kostyantyn Krysan, Yohana Kefella, Lingge Yu, Gregory A. Fishbein, Erika F. Rodriguez, Maryam Shabihkhani, Daniel P. Stefanko, Emily Green, Gang Liu, Hanqiao Liu, Sherry Zhang, Erin Kane, Mitra Mehrad, Avrum E. Spira, Steven M. Dubinett, Eric J. Burks, Sarah A. Mazzilli, Marc E. Lenburg, Jennifer E. Beane
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7205004115
Cites:
Cited by:
Related to: