Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types
Year: 2026
Type: article
Abstract: The Tabula Sapiens is a reference human cell atlas containing single-cell transcriptomic data from more than two dozen organs and tissues. Here, we report Tabula Sapiens 2.0, which includes data from nine new donors, doubles the number of cells, and adds four new tissues. These new data include four donors with multiple organs contributed, thus providing a unique dataset in which genetic background, age, and epigenetic effects are controlled for. We illustrate applications of the Tabula Sapiens data in areas as diverse as gene regulation and aging. The Tabula Sapiens contains transcripts from nearly all human transcription factors, thereby providing putative cell-type specificity for nearly every human transcription factor and insights into their potential regulatory roles. We also analyze the transcriptomes of cells expressing canonical genes relating to cellular senescence, revealing the heterogeneity and context-dependent nature of senescence and providing new hypotheses into senescence-associated pathways.
Source: Cell
Authors: Robert C. Jones, Mark A. Krasnow, Angela Oliveira Pisco, Stephen R. Quake, Julia Salzman, Nir Yosef, Madhav Mantri, Anton Thieme, Jessie Aguirre, Ron Garner, Sal Guerrero, William Harper, Resham Irfan, Sophia Mahfouz, Ravikumar Ponnusamy, Bhavani A. Sanagavarapu, Ahmad Salehi, Ivan Sampson, Chloe Tang, Alan G. Cheng, James M. Gardner, Burnett Kelly, Lindsay Moore, Thurman Slone, Zifa Wang, Anika Nawar Choudhury, Sheela Crasta, George Crowley, Chen Dong, Marcus L. Forst, Doug E. Henze, Jaeyoon Lee, Maurizio Morri, Serena Y. Tan, Sevahn K. Vorperian, Lynn T. Yang, Marcela Alcántara-Hernandez, Julian Berg, Dhruv Bhatt, Sara Billings, Andrès Gottfried-Blackmore, Jamie Bozeman, Simon Bucher, Elisa Caffrey, Amber Casillas, Rebecca Chen, Matthew Choi, Rebecca N. Culver, Ivana Cvijovic, Ke Ding, Hala Shakib Dhowre, Hua Dong, Kenneth Donaville, Lauren Duan, Xiaochen Fan, Mariko H. Foecke, Francisco X. Galdos, Eliza A. Gaylord, Karen Gonzales, William R. Goodyer, Michelle Griffin, Yuchao Gu, Shuo Han, Jun Yan He, Paul Heinrich, Rebeca Arroyo Hornero, Keliana Hui, Juan C. Irwin, SoRi Jang, Annie Jensen, Saswati Karmakar, Jengmin Kang, Hailey Kang, Bikem Soygur, Soochi Kim, Stewart J. Kim, William Kong, Mallory A. Laboulaye, Daniel Lee, Gyehyun Lee, Elise Lelou, Anping Li, Baoxiang Li, Wan-Jin Lu, Hayley Raquer-McKay, Elvira Mennillo, Elena Montauti, Karim Mrouj, Shravani Mukherjee, Patrick Neuhöfer, Saphia Nguyen, Honor Paine, Jennifer B. Parker, Julia Pham, Kiet T. Phong, Pratima Prabala, Zhen Qi, Joshua Quintanilla, Iulia Rusu, Alireza Raissadati, Bronwyn Scott, David Seong, Hosu Sin, Hanbing Song, Sean P. Spencer, Varun R. Subramaniam, Michael Swift, Aditi Swarup, Greg Szot, Aris Taychameekiatchai, Emily Trimm, Stefan Veizades, Sivakamasundari Vijayakumar, Kim Chi Vo, Tian Wang, Timothy T.H. Wu, Yinghua Xie, William Yue, Yue Zhang, Angela Detweiler, Honey Mekonen, Norma F. Neff, Sheryl Paul, Amanda Seng, Jia Yan, Deana Rae Crystal Colburg, Balint Laszlo Forgo, Luca Ghita, Frank McCarthy, Aditi Agrawal, Alina Isakova, Kavita Murthy, Alexandra Psaltis, Wenfei Sun, Kyle Awayan, Pierre Boyeau, Robrecht Cannoodt, Leah Dorman, Samuel D'Souza, Can Ergen, Siyu He, Justin Hong, Harper Hua, Erin McGeever, Antoine de Morree, Luise A. Seeker, Alexander J. Tarashansky, Astrid Gillich, Taha A. Jan, Angela Ling, Abhishek Murti, Nikita Sajai, Ryan M. Samuel, Juliane Winkler, Steven E. Artandi, Philip A. Beachy, Mike F. Clarke, Zev Gartner, Linda C. Giudice, Franklin W. Huang, Juliana Idoyaga, Michael G. Kattah, Christin S. Kuo, Diana J. Laird, Michael T. Longaker, Patricia Nguyen, David Y. Oh, Thomas A. Rando, Kristy Red-Horse, Bruce Wang, Albert Y. Wu, Sean M. Wu, Bo Yu, James Zou
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $11,400
OpenAlex ID: W7205709388