Get started
Work

Tumour rewires host tryptophan metabolism to promote organism-wide immune suppression

Year: 2026
Type: preprint
Abstract: How tumour genotype reshapes systemic metabolism to drive immune tolerance and tumour progression remains unclear. Here, we show that Pten -deficient Drosophila tumours reprogram host tryptophan metabolism, triggering systemic and local changes in immune compartments to foster tolerance. Tumour-derived nitric oxide activates the kynurenine pathway in liver-like tissue, selectively increasing the 3-hydroxykynurenine (3-HK) branch. Host 3-HK promotes tumour progression and suppresses immune function via aryl hydrocarbon receptor (AhR) signalling. These results identify the kynurenine pathway as a central tumour–host nexus and reveal how tumour genotype creates immune vulnerabilities.
DOI: 10.64898/2026.09.02.748262
Authors: Lucia Garcia-Lopez, Ernesto Saez-Carrion, Mary L. Uribe, Carmen Gomez-Escolar, Esther Ballesta-Illan, Jason M. Tennesen, Maria Dominguez
Language: English
Open Access status: green
Funders: European Commission, Generalitat Valenciana, Fundación General CSIC, National Institutes of Health, European Regional Development Fund, National Institute of General Medical Sciences
Awards: G1319223135, G2035821380, G2673512141, COMFUTURO, a public-private collaboration committed to science and the future, G3767523895, G6460844539, G7841057726, G7983413880, Bloomington Drosophila Stock Center at Indiana University, A Drosophila Model for the Regulation of Aerobic Glycolysis
OpenAlex ID: W7207535740
Cites: 1
Cited by:
Related to: 10