Supplementary Tables S1-S10 from Genomic Features Do Not Account for Differences in Multiple Myeloma Risk by Ancestry
Year: 2026
Type: supplementary-materials
Abstract: Supplementary Table 1. Summary of the source of data included in this study. Supplementary Table 2. Summary of demographic and genomic metadata variables collected for patients included in this study. Supplementary Table 3. Comparison of genomic classification events (n = 130) between EUR and AFR Dominant populations in NDMM patients with high ancestry contribution (EUR >0.8 or AFR >0.8). Supplementary Table 4. Comparison of genomic classification events (n = 130) using AFR ancestry as a linear value (linear regression model). Supplementary Table 5. Comparison of genomic classification events (n = 130) between EUR and AFR dominant populations in NDMM patients with high tumor purity (> 0.5) and high coverage (> 40x). Supplementary Table 6. Comparison of genomic classification events between the P1000 EUR group and the GMMG-HD6 cohort. Supplementary Table 7. Odds-ratio comparison for risk of developing multiple myeloma or myeloma precursor conditions for 31 germline SNPs. Supplementary Table 8. Proportion of germline SNPs in APOBEC across AFR and EUR in NDMM. Supplementary Table 9. Subanalysis for comparison of association of APOBEC mutational signatures (SBS2/SBS13) with 31 germline SNPs based on ancestry cluster (EUR, AFR). Supplementary Table 10. The age of multiple myeloma diagnosis from the SEER database.
Authors: Kylee H. Maclachlan, Marios Papadimitriou, Patrick Blaney, Linda B. Baughn, Tala Shekarkhand, Alexandra M. Poos, Bachisio Ziccheddu, Hongwei Tang, Huihuang Yan, Benjamin Diamond, Yanming Zhang, Robert Cimera, Ahmet Dogan, Dylan Gagler, Eileen Boyle, Malin Hultcrantz, Sham Mailankody, Hani Hassoun, Urvi A. Shah, Carlyn Tan, Elizabeth E. Brown, Lara Winterkorn, Timothy Chu, Zoe Steinsnyder, Zalman Vaksman, Faith E. Davies, Neha Korde, Ola Landgren, Marc S. Raab, Alexander M. Lesokhin, Nicolas Robine, Niels Weinhold, Saad Z. Usmani, Francesco Maura, Gareth J. Morgan
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7207774177
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