Matched-Calibration of Changepoint Detectors for Biopharmaceutical Quality Monitoring: analysis and reproduction code
Year: 2026
Type: software
Abstract: Analysis and reproduction code for the manuscript "Matched-Calibration ofChangepoint Detectors for Biopharmaceutical Quality Monitoring" (ScientificReports). The archive provides five changepoint detectors as an importable module -- avariance-scaled BIC-type penalty, a MAD-scaled penalty, windowed variants, aTukey biweight bounded-loss detector, and a permutation test -- together withthe matched false-positive-rate calibration machinery and every experiment andplotting script reported in the paper. Thresholds are calibrated as exact empirical quantiles of each statistic's nulldistribution, using calibration and evaluation samples drawn from independentrandom streams, and all reported rates carry Monte Carlo standard errors. The raw IndPenSim V3 dataset (approximately 2.5 GB) is a third-party resourceand is not redistributed here; the derived batch-end data needed to reproducethe case study is included, and the README states where the full record can beobtained.
Institutions: Istanbul Technical University, Marmara University
Language: English
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W7207799720