Supplementary Figures S1-S10 from Genomic Features Do Not Account for Differences in Multiple Myeloma Risk by Ancestry
Year: 2026
Type: supplementary-materials
Abstract: Supplementary Figure 1. Overview of bioinformatic workflow for each module of the Myeloma Genome Pipeline 1000 (MGP1000). Supplementary Figure 2. Bar plot highlighting the cases where the self-identified race did not match the ancestry. Supplementary Figure 3. Comparison of copy number variation (CNV) and single nucleotide variants (SNV) between African-dominant (AFR) and European-dominant (EUR) admixture clusters. Supplementary Figure 4. Comparison of tumor coverage and purity stratified by admixture cluster assignment. Supplementary Figure 5. Comparison of age and total mutational burden (TMB) stratified by admixture cluster assignment. Supplementary Figure 6. The number of kataegis foci are associated with admixture groups. Supplementary Figure 7. Principal component analysis (PCA) plots generated via EIGENSTRAT for the AFR Dominant population. Supplementary Figure 8. Haplotype distribution at each of 6 significantly distributed SNPs from those comprising the PRS. Supplementary Figure 9. Relationship between polygenic risk score (PRS), APOBEC activity and APOBEC SNP genotypes. Supplementary Figure 10. APOBEC (SBS2/SBS13) contribution by Admixture group and pre/post-gain stage.
Authors: Kylee H. Maclachlan, Marios Papadimitriou, Patrick Blaney, Linda B. Baughn, Tala Shekarkhand, Alexandra M. Poos, Bachisio Ziccheddu, Hongwei Tang, Huihuang Yan, Benjamin Diamond, Yanming Zhang, Robert Cimera, Ahmet Dogan, Dylan Gagler, Eileen Boyle, Malin Hultcrantz, Sham Mailankody, Hani Hassoun, Urvi A. Shah, Carlyn Tan, Elizabeth E. Brown, Lara Winterkorn, Timothy Chu, Zoe Steinsnyder, Zalman Vaksman, Faith E. Davies, Neha Korde, Ola Landgren, Marc S. Raab, Alexander M. Lesokhin, Nicolas Robine, Niels Weinhold, Saad Z. Usmani, Francesco Maura, Gareth J. Morgan
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7207833758
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