Year: 2018
Type: article
Abstract: Tissue plasminogen activator (tPA)is effective if administered within 3 -4 .5 hours after the onset of stroke.However, its use is limited in patients with ischemic stroke because of the narrow therapeutic time window available for safe and effective therapy, beyond which tPA may increase the incidence of intracerebral hemorrhage and further brain injury.ADAMTS13 is known to cleave von willebrand factor (VWF)on the surface of platelet thrombi in a shear force-dependent manner, which limits thrombus growth.Thus, ADAMTS 13 dissolves only pathological thrombi and not VWF-platelet primary hemostatic thrombi, and may therefore have a low risk of inducing intracerebral hemorrhage following dissolution of thrombi in ischemic stroke.In this study, we investigated whether ADAMTS 13 -deficiency enhanced microcirculatory disturbances after cerebral ischemia.ADAMTS 13 gene knockout (KO)and wild-type(WT)mice were subjected to 30 -minute middle cerebral artery occlusion(MCAO)and 23 .5 -hour reperfusion.The cerebral blood flow(CBF)around the cortex of the ischemic region was measured by
Author: 中野 貴文
Language: Japanese
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2788551684