Year: 2022
Type: dissertation
Study design: Observational Study
Abstract: Background: Symptoms of obsessive-compulsive disorder (OCD) have been conceptualized as manifestations of decision-making deficits.Patients with OCD exhibit impairment during the decision-making process, as assessed by the Iowa Gambling Task (IGT).This impairment is independent of clinical severity and disease progression.However, the association between the decision-making deficit and resting-state brain activity of patients with OCD has not been examined.Methods: Fifty unmedicated patients with OCD and 55 matched control subjects completed IGT.Resting-state brain activity was examined using the fractional amplitude of low-frequency fluctuations (fALFFs).fALFF analysis focused on the slow-4 and 5 bands.Group comparisons were performed to determine the association between IGT performance and fALFFs.Results: There was a significant group difference in the association between the IGT total net score and slow-4 fALFFs in the left putamen (voxel height threshold of p < 0.001; cluster size threshold of p < 0.05; family wise error-corrected).Higher putamen slow-4 fALFFs were correlated with lower IGT scores for OCD patients (r = -0.485;p < 0.0005) and higher IGT scores for control subjects (r = 0.402; p < 0.005).There was no group difference in the association between the IGT total net score and slow-5 fALFFs.Conclusions: These findings in unmedicated patients demonstrate the importance of resting-state putamen activity for decision-making deficit associated with OCD, as measured by IGT.The inverse correlation may be explained by the hypersensitive response of the putamen in patients with OCD.
Author: HASUZAWA, Suguru
Institution: Kyushu University
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W7208355013