腸疾患の既往のない整形外科患者における口腔から直腸への微生物伝播
Year: 2025
Type: dissertation
Study design: Observational Study
Abstract: The enrichment of oral taxa in the gut has recently been reported as a notable alteration in the microbial balance in patients with intestinal disorders.However, translocation in populations without such diseases remains controversial.In this study, we examined 49 pairs of tongue and rectal samples collected from orthopedic patients without a history of intestinal disorders to verify the presence of oral taxa in the rectal microbiota.The bacterial composition of each sample was determined using 16S rRNA gene sequencing and amplicon sequence variant (ASV) analysis.Although the bacterial compositions of the tongue and rectal microbiota were distinctly different, tongue ASVs were detected in 67.3% of the participants and accounted for 0.0%-9.37% of the rectal microbiota.Particularly, Streptococcus salivarius, Fusobacterium nucleatum, and Streptococcus parasanguinis were abundant in the rectal microbiota.According to the network analysis, tongue taxa, such as S. salivarius and S. parasanguinis, formed a cohabiting group with Klebsiella pneumoniae and Alistipes finegoldii in the rectal microbiota.The total abundance of tongue ASVs in the rectal microbiota was significantly higher in participants with older age, hypertension, and proton pump inhibitor (PPI) use.Our study presents an extensive translocation of oral taxa to the rectum of a population without intestinal disorders and suggests that aging, hypertension, and PPI use are associated with an increased abundance of oral taxa and potential pathogenic bacteria in the rectal microbiota.
Author: 林, 鴿
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Elucidation of the long-term dynamics of oral microbiota and factors associated with the dysbiosis based on a 15-year cohort study, 口腔細菌が引き金となる腸管dysbiosisの理解とその予防に向けたリスク因子の特定, Identification of oral microbiota associated with oral bacterial colonization in gut, Translocation of oral bacteria to the gut in community-dwelling adults, Understanding of disrupted oral mirobiota colonized by non-oral taxa and its association with host's health conditions
OpenAlex ID: W7080967119