Activation of AMP-activated Protein Kinase Decreases Receptor Activator of NF-kB Ligand Expression And Increases Sclerostin Expression by Inhibiting the Mevalonate Pathway in Osteocytic MLO-Y4 Cells
Type: dissertation
Abstract: Previous studies have shown that AMP-activated protein kinase (AMPK) plays important roles in bone remodeling.However, little is known about the roles of AMPK in osteocytes.There are no reports examining effects of AMPK activation on the expressions of RANKL and sclerostin in osteocytes.This is the first study showing AMPK activation decreases RANKL expression and increases sclerostin expression in osteocytic MLO-Y4 cells by inhibiting mevalonate pathway.We feel that the findings described in this article will be of special interest to the readers of Biochemical and Biophysical Research Communications.
Author: 横本, 真希
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7208541540