Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes
Year: 2026
Type: article
Study design: Observational Study
Abstract: ). Removing major histocompatibility complex SNPs abolished associations with known autoimmune diseases, while all other associations remained. We replicated 17 (42.5%) of 40 significant phenotypes available in the Vanderbilt University Medical Center's BioVU. Our findings demonstrate that systemic inflammation can be predicted using the iPRS across multiple ancestries, and the iPRS is associated with numerous clinical endpoints. This multi-ancestry iPRS may have future utility in stratifying risk for inflammation-driven conditions across diverse populations.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,300
Funders: Wellcome Trust, Vanderbilt University Medical Center, Georgia Clinical and Translational Science Alliance, National Institutes of Health, Medical College of Wisconsin Cancer Center, National Human Genome Research Institute, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: Genomic Epidemiology and Public Health Genomics, G2683268942, G364208108, G3978466315, Automated Storage and Retrieval of Biological Systems, G6012682559, Genomic Epidemiology and Public Health Genomics, The Vanderbilt Institute for Clinical and Translational Research (VICTR), G8882569155, Building Interdisciplinary Research Careers in Women's Health, Polygenic risk scores for cardiometabolic disorders: the role of blood cells immune response and evolutionary adaptation
OpenAlex ID: W7208711674