Dramatic acceleration by silica gel under highly concentrated conditions: Aromatic halogenation and nitroaldol (Henry) reactions
Year: 2026
Type: preprint
Abstract: Dramatic acceleration of aromatic halogenation and nitroaldol (Henry) reactions was achieved by the addition of silica gel under highly concentrated conditions. Bromination, chlorination, and iodination of various aromatic substrates were examined in the presence of silica gel under highly concentrated conditions, and significant acceleration was observed for many substrates compared with conventional conditions. The combination of silica gel and highly concentrated conditions also markedly accelerated nitroaldol (Henry) reactions of aliphatic and aromatic aldehydes. Silica gel could be recovered and reused in both halogenation and nitroaldol reactions without significant loss of activity. These results demonstrate a simple, efficient, and more sustainable protocol for promoting important organic transformations.
Source: ChemRxiv
Author: Kiyoshi Tanemura
Institution: Nippon Dental University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7208717761