Patient-Specific Biomimetic Neural Reconstruction for Traumatic Brain Injury
Year: 2026
Type: preprint
Abstract: Traumatic brain injury (TBI) can result in permanent neurological dysfunction through neuronal loss, axonal disruption, demyelination, neuroinflammation, and disruption of distributed neural networks. Diffuse axonal injury (DAI) represents a particularly difficult therapeutic problem because its pathology is characterized by widespread disruption of axons and white-matter pathways rather than a single surgically removable lesion. Current regenerative approaches have investigated neural stem/progenitor cells, biomaterial scaffolds, tissue engineering, 3D bioprinting, remyelination, and electrical neuromodulation. However, most strategies target individual components of neural repair rather than attempting patient-specific reconstruction of the anatomical and biological environment of the injured tissue.
Author: Mohamed, Abdelrahman Amr
Institution: Alexandria University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7208727719
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