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Relation of Self-Reported Race and Genetic Ancestry to Hypertension Prevalence Among Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos

Year: 2026
Type: preprint
Study design: Observational Study
Abstract: ABSTRACT Background The imprecision of current metrics to capture the complex genetic admixture and racial identity among Hispanic/Latino individuals in the United States (US) is a concern. We examined the relationship of self-reported race and genetic ancestry with hypertension (HTN) among Hispanics/Latinos. Methods Cross-sectional study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), including 10,586 Hispanic/Latino unrelated adults. Genetic ancestry: West African (AA), Amerindian (AI), and European (EA). Self-reported race: White, Black, Native American, or Multiple/Missing ( More than one race or Unknown/Not reported/Refused ). HTN: systolic (SBP) ≥130 mmHg, diastolic blood pressure (DBP) ≥80 mmHg, and/or use of HTN medications. Age- and sex adjusted models were used. Results Self-reported race was White (38·6%), Black (3·6%), Native American (4·1%), and Multiple/Missing (53·7%), with Unknown/Not reported/Refused representing 32·7%. Black and White Hispanics/Latinos had the greatest AA (55·7%) and EA (69·3%) ancestries, respectively. Each 10% AA increase was associated with OR 1·15, SBP beta +0.9 mmHg, and DBP beta +0.7 mmHg. Conversely, each 10% AI increase was associated with OR 0·83, SBP beta -0·4 mmHg, and DBP beta -0·6 mmHg. HTN prevalence was highest among those with Black race or in the highest AA quantile (45·6% and 48·0%, respectively), and lowest among those with Native American race or in the highest AI quantile (37·6% and 26·7%, respectively). Conclusion One-third of Hispanics/Latinos did not self-report race. Black or White self-reporting race did somewhat relate to AA or EA ancestry, respectively. HTN profiles were related to self-reported race and genetic ancestry in this admixed population.
Source: medRxiv
DOI: 10.64898/2026.09.01.26361995
Authors: Raul A Montanez-Valverde, Vivian Kim, Priscilla A Duran Luciano, Yawen Yuan, Tamar Sofer, Robert Kaplan, Linda C Gallo, Gregory A Talavera, Krista M Perreira, Martha Daviglus, Sylvia E Rosas, Maria M Llabre, Tali Elfassy, Xihao Li, Carmen R Isasi, Carlos J Rodriguez
Institutions: Albert Einstein College of Medicine, Montefiore Medical Center, Beth Israel Deaconess Medical Center, Harvard University, San Diego State University, University of North Carolina at Chapel Hill, University of Illinois Chicago, Joslin Diabetes Center, University of Miami
Language: English
Field: Medicine
Open Access status: green
Funders: Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, National Institutes of Health, University of Illinois at Urbana-Champaign, Gillings School of Public Health, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities
OpenAlex ID: W7208736778
Cites: 42
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