Work

Clinical‐State Validation Should Precede Patient‐Level Use of Glioma Connectivity Anomaly Maps

Year: 2026

Type: article

Abstract: Multimodal anomaly maps can reveal distributed structural and functional connectivity deviations in glioma, but resting-state functional connectivity also reflects scan-day motion, vigilance, symptoms, seizures, and medication exposure. We propose prespecifying whether the target is tumor-associated alteration, all-cause patient-state deviation, or prognosis; recording a compact clinical-state vector; auditing state leakage and repeatability; and externally validating incremental clinical value before patient-level use.

Source: NMR in Biomedicine

DOI: 10.1002/nbm.70391

Authors: Siang‐Syuan Kong, Lien‐Chung Wei

Institutions: Ministry of Health and Welfare, Kainan University, Ming Chuan University

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7208738943

FWCI:

Cites: 5

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