Work

A case report on the pathogenesis of BAP1 inactivating melanocytomas (BIMTs)

Year: 2026

Type: article

Abstract: BAP1-inactivated melanocytic tumors (BIMTs) are rare, diagnostically challenging skin lesions that require histopathological and molecular evaluation for accurate diagnosis. We present a case of a 50-year-old female diagnosed with a BIMT on the skin overlying her upper right trapezius noted during a comprehensive full body skin examination. Dermatopathological analysis confirmed the presence of a BAP1-inactivating melanocytoma, with positive staining for S100, SOX10, and P16, negative staining for p63, CD68, and PRAME and loss of BAP1 nuclear expression. This case reveals the importance of thorough skin examinations and genetic counseling in patients with BAP1-inactivated melanocytic lesions.

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2026.08.048

Authors: Alexander Michael Diaz, Lawrence Adam Schiffman, Evan Miller, Stephen M. Schleicher

Institutions: St. George's University, Instituto de Dermatologia Dona Libania, Gabba Dermatology, DermDox Dermatology Centers

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750