Nickel/Photoredox‐Catalyzed Dicarbofunctionalization of Alkenes via Ketone C─C Bond Cleavage: Access to an Enantioselective Variant
Year: 2026
Type: article
Abstract: ABSTRACT In this study, we disclose a general protocol for the three‐component difunctionalization of alkenes using nickel catalysis and aliphatic carbonyl precursors that are activated by sp 3 C─C bond cleavage. Under visible‐light irradiation, this transformation provides an efficient strategy to install two vicinal carbon─carbon bonds across alkenes from easily accessible precursors. Notably, the alkene difunctionalization was extended to an enantioselective variant, providing streamlined access to complex enantioenriched scaffolds. The reaction exhibits operational simplicity, broad substrate scope, and excellent regioselectivity and chemoselectivity while demonstrating compatibility with bioactive motifs and the ability to expedite the synthesis of pharmaceutically relevant molecules.
DOI: 10.1002/anie.2368387
Institutions: Shihezi University, University of Copenhagen
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G2134249794, G6458882965
OpenAlex ID: W7208746622