Year: 2026
Type: article
Abstract: Morphogenesis, the process by which cells, tissues, and organs acquire and maintain their form, is essential for embryogenesis, regeneration, and disease progression. During morphogenesis, cells within tissues dynamically interact with biophysical and biochemical signals from their environment by modifying their shape, gene expression, and function. These modifications often lead to transitions between cell states, and with that, to the establishment of functional programs that will in turn define embryonic stages or tissue states. Here, we discuss how the interplay of gene expression programs, chromatin modifications, and biophysical factors from the microenvironment contributes to the robust coordination of morphogenesis by allowing cells within tissues to dynamically transit across functional stages.
Source: The EMBO Journal
Institutions: Physics of Life, Technische Universität Dresden
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $7,990
Awards: EXC 2068: Physik des Lebens Die dynamische Organisation lebender Materie (PoL), G2342545529, Mechanical and Electrical Guidance of Collective Cell Migration in vivo, Signaling and extrinsic forces leading to differentiation of neural crest cells to form ganglia of the peripheral nervous system, G541433245, G6381955724, Mechano-epigenetic control of neural crest collective cell migration in vivo, G7561649996
OpenAlex ID: W7208749313