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Creatine monohydrate supplementation: one tool in the toolbox for treating sarcopenia

Year: 2026

Type: article

Abstract: Sarcopenia, characterized by age-related reductions in muscle performance (primarily maximal strength), muscle quality, lean mass and functional ability, is a growing global health concern. This paper explores the potential of creatine monohydrate supplementation (CrM) as a safe and therapeutic strategy for the treatment of sarcopenia. Multiple systematic reviews and meta-analyses have demonstrated the efficacy of CrM, particularly when combined with resistance exercise, for improving key aspects of muscle health (i.e., whole-body lean mass, limb muscle thickness and density, muscle strength and functional ability) in older adult populations. However, the effects of CrM in older adults diagnosed with sarcopenia is relatively unknown. Although CrM is promising, emphasis is placed on its role as part of a comprehensive approach in the treatment of sarcopenia, which includes adequate protein and vitamin D replacement/supplementation when necessary and structured resistance exercise.

Source: Longevity

DOI: 10.1080/30653495.2026.2727350

Authors: Darren G. Candow, Ste Traxler, Philip D. Chilibeck, Scott C. Forbes, Sergej M. Ostojic, Jeffrey R. Stout, Jose Antonio, Richard B. Kreider, Diego A. Bonilla, Michael D. Roberts, Mark A. Tarnopolsky, Fabrizio Angelini, Nicholas Fabiano

Institutions: University of Regina, University of Saskatchewan, Brandon University, Texas Tech University, University of Central Florida, Nova Southeastern University, Texas A&M University, University of the Basque Country, Auburn University, McMaster Children's Hospital, University of Ottawa

Language: English

Topic: Nutrition and Health in Aging

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7208752762

FWCI:

Cites: 104

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