Year: 2026
Type: article
Abstract: Niobium‐based MXenes exhibitefficient near‐infrared (NIR) absorption but remain underexplored for in vivo cancer therapy. In this study, we investigated Nb 4 C 3 T x MXene as an NIR‐II photothermal therapy (PTT) sensitizer for melanoma. Both in vitro and in vivo experiments were performed using Nb 4 C 3 T x in combination with pulsed 1064 nm laser irradiation. Tumor growth, histological changes, and spatial localization of MXene were assessed to evaluate therapeutic efficacy and safety. Nb 4 C 3 T x significantly enhanced tumor suppression under pulsed NIR‐II irradiation, inducing extensive destruction of melanoma cells while sparing surrounding tissue. Histological analysis revealed macrophage‐mediated uptake and clearance of MXene, with no evidence of persistent accumulation in tumor remnants or visceral organs. Pulsed laser irradiation provided precise and rapid heating, improving treatment accuracy and minimizing collateral damage. However, complete tumor eradication was not achieved, likely owing to limited light penetration in bulky tumors and the nontargeted distribution of pristine MXene. Our study demonstrates the feasibility and safety of Nb 4 C 3 T x MXene‐assisted PTT in vivo, providing the first experimental evidence of its therapeutic potential in melanoma treatment. These findings establish Nb 4 C 3 T x as a promising platform for pulsed laser–mediated PTT, while highlighting the need for targeted functionalization and treatment optimization to achieve selective tumor ablation.
Source: Advanced NanoBiomed Research
DOI: 10.1002/anbr.70157
Authors: Anton Roshchupkin, Benjamin Chacon, Gulnaz Gahramanova, Inna Chorna, Zhanna Klishchova, Anastasia Konieva, Ilya Yanko, Andrii Liutyi, Milena Yalyzhko, Ivan Baginskiy, Veronika Zahorodna, Júlio Sílvio de Sousa Bueno Filho, Erfan Rezvani Ghomi, Igor Panko, Tetiana Shapochka, Oksana Sulaieva, Oleksandr Solodovnyk, Lucia Gemma Delogu, Oleksiy Gogotsi, Laura Fusco, Sergiy Kyrylenko, Yury Gogotsi, Maksym Pogorielov
Institutions: Sumy State University, Drexel University, Azerbaijan State Oil and Industry University, Universidade Federal de Lavras, Essen University Hospital, Materials Research Center (Ukraine), Nanyang Technological University, Kyiv Medical University, University of Padua, Khalifa University of Science and Technology, University of Latvia
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,940
OpenAlex ID: W7208808160