Dinutuximab beta with TEMIRI chemotherapy in relapsed/refractory neuroblastoma: Real-world insights into the open question of GD2 expression

Year: 2026

Type: article

Abstract: INTRODUCTION: Prognosis of Relapsed/Refractory (R/R) neuroblastoma is still dismal. Chemoimmunotherapy has been reported to improve the response rate. PATIENTS AND METHODS: /day for 4 consecutive days. RESULTS: Twenty-five children received chemo-immunotherapy. Hematological toxicity was the most common adverse event. The best overall response rate (ORR) was 52% (95% CI:31-72), with an ORR of 62% (95% CI: 38-82) at metastatic sites. Responses were higher at bone and bone marrow sites (ORR 67% and 92%, respectively). SIOPEN skeletal score declined during treatment, the best response being observed after the first 2/3 courses. Primary tumors and soft-tissue lesions were less responsive, though metabolic activity often decreased. Negative or low GD2 expression was observed in 10% and in 35% of tumor tissue, respectively at baseline and after treatment, with mean GD2-positive tumor cells decreasing from 88% to 62% in tumor tissue, mainly associated with differentiating histology. DISCUSSION: This real-world experience confirms that a short schedule is a feasible and effective option in R/R neuroblastoma. The dynamic and heterogeneous expression of GD2 deserves further evaluation, particularly in relation to selection of patients and subsequent GD2-directed treatment strategies.

Source: Translational Oncology

DOI: 10.1016/j.tranon.2026.103013

Institutions: Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, Università Cattolica del Sacro Cuore

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390

Funder: Ministero della Salute

OpenAlex ID: W7208832207