Work

Continuous glucose monitoring detects spontaneous reactive and fasting hypoglycaemia in cystic fibrosis adults without diabetes

Year: 2026

Type: article

Abstract: People with cystic fibrosis (pwCF) experience a spectrum of glucose disorders. Spontaneous hypoglycaemia is a unique entity affecting pwCF and can be an incidental finding on biochemistry. Our prospective, single-arm pilot study of eight pwCF without confirmed diabetes and incidental biochemical hypoglycaemia found 62.5% demonstrated fasting or reactive hypoglycaemia on continuous glucose monitoring (CGM). The remaining individuals without hypoglycaemia on CGM demonstrated dysglycaemia consistent with pre-diabetes. Symptomatic spontaneous hypoglycaemia captured on CGM was successfully managed with dietary modifications and dipeptidyl peptidase-4 inhibitor in all participants. Whether spontaneous hypoglycaemia precedes progression to pre-diabetes and overt diabetes in pwCF requires further evaluation.

Source: Internal Medicine Journal

DOI: 10.1111/imj.70626

Authors: Shanal Kumar, Karen Hay, Felicity Loel, Angela Matson

Institutions: The University of Queensland, Prince Charles Hospital, QIMR Berghofer Medical Research Institute

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,570