Effects of single-trial averaging on spatial extent of brain activation detected by fMRI are subject and task dependent
Year: 2006
Type: article
Abstract: AIM: The effects of single-trial averaging on the spatial extent of event-related fMRI activation may vary between subjects and tasks. The purpose of this study was to evaluate this variability using a visual task and a word generation task. PATIENTS, MATERIALS, AND METHODS: Five Chinese right-handed male volunteers participated in the experiment. Experiments were conducted using a 1.5 T clinical MRI scanner with a T2*-weighted single-shot gradient-echo EPI sequence. Each task contained 150 trials that were separated into 5 runs. For each voxel, time courses averaged across different numbers of randomly selected trials, were obtained. They were applied for determining the voxels with significant activations, using a students' t-test (p<0.001, uncorrected). RESULTS: Consistent with previous findings, the number of the activated voxels increased monotonically with the number of trials combined. The ascending rate and the maximum number of the activated voxels were different, however, between tasks and among subjects. CONCLUSIONS: The effects of single-trial averaging were found to vary significantly between tasks and subjects. Therefore, we strongly advise to carefully consider such variability when using the spatial extent of activation as a measure in a group or a task comparison.
DOI: 10.2349/biij.2.2.e27
Authors: S.Y. Fang, J.J. Wang, Y.Y. Hsu, Y.L. Wan, Y.Y. Wai, H.L. Liu
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W1969037102