A Multi-Omics Study of Cognitive Resilience to Alzheimer’s Disease
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Alzheimer's disease (AD) is the most severe form of dementia. While significant efforts have been made to identify AD risk factors and develop therapeutics, much less attention has been given to neurobiological factors and molecular signatures associated with cognitive resilience. Substantial evidence suggests that modifiable factors, such as physical and mental activity, may contribute to cognitive reserve and resilience. To this end, we developed a resilient cohort of paired genetics, transcriptomics and proteomics data from the prefrontal cortex of 282 cognitively normal older adults. We conducted extensive preprocessing and rigorous quality control (QC), including QC on sequence metrics and sample matching across multiomics. This cohort can be leveraged for identification of molecular signatures of cognitive resilience to AD and is freely shared with the research community.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Epidemiologic Study of Neural Reserve and Neurobiology of Aging, Integrative Network Modeling of Cognitive Resilience to Alzheimer's Disease, Multi-scale analysis of single cell sequencing data to dissect the complexity of influenza infections, Mechanisms of Susceptibility of Excitatory Neurons to Tau Pathology and Neurodegeneration in Alzheimer's disease, Integrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's Disease, Molecular Characterization and Validation of Gender Differences in Alzheimers Disease Pathogenesis, Pathway discovery, validation and compound identification for Alzheimer's disease, Big Omics Data Engine 2 Supercomputer, Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's Disease, Risk Factors, Pathology, and Clinical Expressions of AD, Towards a comprehensive signaling pathway map of parahippocampal vulnerability in Alzheimers Disease, Rush Alzheimer's Disease Core Center, VGF peptide TLQP-21, a novel microglial C3aR1 modulator in Alzheimer's disease, Dissect the interplay between sex and APOE at the single cell level to uncover novel pathways, targets and therapeutics for Alzheimer's disease, Systems modeling of shared and distinct molecular mechanisms underlying comorbid Major Depressive Disorder and Alzheimer's disease, Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targets, Transcriptome and Network Analysis of Cleft Palate, COVID and Translational Science supercomputer (CATS), Identification and characterization of AD risk networks using multi-dimensional "omics" data, Conduits: Mount Sinai Health System Translational Science Hub, Molecular Neurobiology of Human Opioid Use Disorder, Rush Alzheimer's Disease Research Center
OpenAlex ID: W7210281326