Interventional Treatment of Arterial Hypertension in The Modern Era: An Updated Review from the Young Investigator Group of the European Society of Hypertension
Year: 2026
Type: article
Abstract: Achievement of blood pressure targets in hypertensive patients is a challenge for clinicians despite the different classes of drugs currently available. For this reason, taking advantage of the technological progress, new interventional strategies have been proposed. Each of these approaches acts on autonomic and vascular regulation, critical components of hypertension pathophysiology with the aim to recalibrate aberrant sympathetic activation and vascular dysfunction. Renal artery denervation is the only modality currently supported by guideline recommendations in selected patients. Baroreflex activation therapy, and carotid body modulation, thanks to good experimental results, are under evaluation as promising strategies. Concurrently, newer modalities, such as deep brain stimulation, cardiac neuromodulation, and arteriovenous shunts, are emerging with promising early data. The present narrative review provides an overview of interventional treatments for hypertension, describing their efficacy, mechanism of action, safety, and side effects. As clinical research progresses, there is the possibility that these techniques will emerge as promising treatment options for patients with resistant hypertension in the near future.
Institutions: Erasmus MC, University of Naples Federico II, Grigore T. Popa University of Medicine and Pharmacy, University of Rijeka, National and Kapodistrian University of Athens, Sotiria General Hospital, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Hospital de São João, University of Belgrade, Univerzitetski Klinički Centar Srbije, University of Liège, Centre Hospitalier Universitaire de Liège, Masaryk University, St. Anne's University Hospital Brno, Klinički Bolnički Centar Split, Ljubljana University Medical Centre, University of Ljubljana, International Hellenic University, European University Cyprus
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,890
OpenAlex ID: W7210290457