Year: 2026
Type: article
Study design: Observational Study
Abstract: Importance : To be aware of central serous chorioretinopathy among patients with mental health co-morbidities and improve diagnosis and timely referral. Objective : To describe the association of selected mental health conditions with central serous chorioretinopathy. Design : A cross-sectional study from the All of Us Research Program with data collected from 2014 to 2025 and analyzed in 2025. Cases were identified using ICD-9/10 and SNOMED codes and compared to propensity score-matched controls. Setting A population-based study from All of Us , a national, multicenter initiative designed to reflect the diversity of the U.S. population. Participants 568 adult patients with central serous chorioretinopathy were identified. 1,704 controls were selected using 1:3 propensity score matching on age, gender, race, ethnicity, annual household income, and education level. Exposure(s) (for observational studies) Depression, anxiety, obsessive-compulsive disorders, and trauma-related disorders were identified using ICD-9/10 and SNOMED codes. Main Outcome(s) and Measure(s) We used multiple logistic regression models to assess the association between central serous chorioretinopathy and each mental health condition, adjusting for covariates including demographic factors, corticosteroid use, and obstructive sleep apnea. Results : In comprehensive models adjusting for sociodemographic factors, clinical comorbidities, and all other selected mental health conditions, depression (OR = 1.68, 95% CI: 1.26–2.23, p < 0.001) and trauma-related disorders (OR = 1.45, 95% CI: 1.07–1.97, p = 0.016) remained significant predictors of central serous chorioretinopathy. In independent models, depression, anxiety, and trauma-related disorders were individually significant (depression OR = 2.02; 95% CI: 1.57–2.59; p < 0.001, anxiety OR = 1.78; 95% CI: 1.28–2.46; p = 0.003, and trauma-related disorders OR = 1.88; 95% CI: 1.42–2.48; p < 0.001). Conclusions and Relevance Adults with depression, anxiety, and trauma-related disorders were more likely to have central serous chorioretinopathy compared to controls. Psychiatrists need to be aware of the mental health conditions commonly associated with central serous chorioretinopathy to support timely identification and proper referral to an ophthalmologist.
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,630
OpenAlex ID: W7210290970