Work

Ir/Rh-catalyzed hydrogenation of squalene: access to stereoregular squalane

Year: 2026

Type: article

Abstract: C NMR spectroscopy of crude reaction mixtures, without derivatization or chromatographic separation. Buried-volume analysis was used to compare the steric environment of the selective Ir catalyst with representative non-selective systems, providing a qualitative interpretation of the observed behaviour. To our knowledge, this work provides the first catalytic access to stereoregular squalane and establishes a practical NMR-based approach to evaluate stereochemical bias in hydrogenated isoprenoid hydrocarbons.

Source: RSC Advances

DOI: 10.1039/d6ra05192h

Authors: Teresa Iovine, Christian Ehm, Umesh I. Kaluarachchige Don, Vincenzo Busico, Adam S. Veige, Roberta Cipullo

Institutions: University of Naples Federico II, University of Florida

Language: English

Topic: Asymmetric Hydrogenation and Catalysis

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

OpenAlex ID: W7211869420

FWCI:

Cites: 45

Cited by:

Related to: 10