Work

Nucleophilic Reactions of Cyclobutenones and the Related 4,4‐Dichlorocyclobutenone Derivatives

Year: 2026

Type: article

Abstract: Cyclobutenones have uninterrupted attention as useful synthons in the synthesis of complex organic molecules. Much of that interest is directed toward strain‐release reactions, a result of the inherent ring‐strain four‐membered ring exacerbated by the embedded enone functionality in the cyclobutenone framework. Little attention is paid to the nucleophilic reactions of the cyclobutenone nucleus and their 4,4‐dichloro analogs. These reactions are often found dispersed in literature, and this review is our attempt to bring these reactions to the attention of the synthesis organic chemistry community.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70837

Authors: Sarah J. Wright, Muhluri H. Mthombeni, Songeziwe Ntsimango

Institutions: University of the Witwatersrand, Rhodes University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funder: Rhodes University