Congenital syphilis outcomes by penicillin dosing intervals among women with late latent or latent of unknown duration syphilis during pregnancy in eight U.S. jurisdictions: 2018-2023
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Pregnant women with late latent or latent of unknown duration syphilis are recommended to receive three doses of benzathine penicillin G each 9 or fewer days apart; data on interval variations are limited. We found no significant difference in risk of congenital syphilis between 9-day and 6-8 day dosing intervals. Summary Among pregnant women with late latent or latent of unknown duration syphilis, there was no difference in risk of congenital syphilis between 9-day and 6-8 day maternal treatment dosing intervals.
Source: medRxiv
Institutions: Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention, Arizona Department of Health Services, Michigan Department of Health and Human Services, New Jersey Department of Health, Arkansas Department of Health, Washington State Department of Health, New York State Department of Health, Maricopa County Department of Public Health, Georgia Department of Public Health
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G4611699547, G464474549, G7155667267
OpenAlex ID: W7211960953