Lumbar puncture and the diagnosis of aneurysmal subarachnoid haemorrhage – a ten-year service evaluation
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Objectives Aneurysmal subarachnoid haemorrhage is a life-threatening emergency that commonly presents with a sudden, severe headache. The diagnosis is usually confirmed on CT imaging, however a small subset of patients demonstrate normal imaging, particularly if presentation is delayed – in which case spectrophotometric analysis of cerebrospinal fluid (CSF) is undertaken. Nevertheless, thunderclap headache is a common presentation and the vast majority of investigated patients do not have aneurysmal subarachnoid haemorrhage. This ten-year service evaluation at a tertiary neurosurgery centre aims to estimate the utility of lumbar puncture in the diagnostic work-up of these patients. Methods All instances of CSF spectrophotometry between 01/01/2011 and 31/12/2020 were evaluated. Clinical records of patients with positive spectrophotometry were analysed. A second method identified all coded diagnoses of non-traumatic subarachnoid haemorrhage over the same time period, with review of clinical records in cases of negative imaging. Results Of 2158 instances of CSF spectrophotometry performed at the tertiary neurosurgery centre, four aneurysms were identified and treated by coiling or clipping, resulting in a number needed to treat of 540 patients to diagnose one case of aneurysmal subarachnoid haemorrhage. Of 648 patients with a coded diagnosis of non-traumatic subarachnoid haemorrhage (including local patients and transfers from satellite hospitals), 27 patients displayed initial negative imaging, of which 9 were found to have aneurysms and underwent neuro-intervention. Lumbar puncture was instrumental in the diagnosis and led to intervention in three patients identified by this method. Conclusion CSF analysis resulted in diagnosis and intervention for missed (CT-negative) aneurysmal subarachnoid haemorrhage in approximately 1/540 tested patients. The estimated yield in a real-world setting may be useful for clinicians or provide a basis for discussion when counselling patients on benefit and risk.
Source: medRxiv
Authors: Jamie Talbot, Daniel Lashley
Institution: Derriford Hospital
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7211991930